Effect of dental amalgam on gene expression profiles in rat cerebrum, cerebellum, liver and kidney

 

    

 

 

Takahashi Y <http://www.ncbi.nlm.nih.gov/pubmed?term=Takahashi%20Y%5BAuthor%5D&cauthor=true&cauthor_uid=22688007> , Tsuruta S <http://www.ncbi.nlm.nih.gov/pubmed?term=Tsuruta%20S%5BAuthor%5D&cauthor=true&cauthor_uid=22688007> , Honda A <http://www.ncbi.nlm.nih.gov/pubmed?term=Honda%20A%5BAuthor%5D&cauthor=true&cauthor_uid=22688007> , Fujiwara Y <http://www.ncbi.nlm.nih.gov/pubmed?term=Fujiwara%20Y%5BAuthor%5D&cauthor=true&cauthor_uid=22688007> , Satoh M <http://www.ncbi.nlm.nih.gov/pubmed?term=Satoh%20M%5BAuthor%5D&cauthor=true&cauthor_uid=22688007> , Yasutake A <http://www.ncbi.nlm.nih.gov/pubmed?term=Yasutake%20A%5BAuthor%5D&cauthor=true&cauthor_uid=22688007> .

Department of Dental Material Science, School of Dentistry, Aichi Gakuin University, Aichi, Japan. yoshi@dpc.agu.ac.jp

J Toxicol Sci. 2012;37(3):663-6.

Icon for J-STAGE, Japan Science and Technology Information Aggregator, Electronic

 

 

Abstract

 

 

Dental amalgam is a source of exposure to elemental mercury vapor in the general population. The aim of this study was to elucidate the effect of elemental mercury vapor exposure from dental amalgam restorations on gene expression profiles. Out of 26,962 rat genes, mercury vapor was found to increase the expression of 1 gene (Atp1b3) and decrease the expression of 1 gene (Tap1) in the cerebrum, increase the expression of 1 gene (Dnaja2) in the cerebellum, increase the expression of 2 genes (Actb and Timm23) and decrease the expression of 1 gene (Spink3) in the liver, increase the expression of 2 genes (RT1-Bb and Mgat5) and decrease the expression of 6 genes (Tnfaip8, Rara, Slc2a4, Wdr12, Pias4 and Timm13) in the kidney.

<http://joi.jlc.jst.go.jp/DN/JST.JSTAGE/jts/37.663?lang=en&from=PubMed